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https://www.phaser.cimr.cam.ac.uk/index.php/Course
Course
2023-10-16T09:49:27Z
<p>WikiSysop: </p>
<hr />
<div>The Macromolecular Crystallography course was presented in the 1999-2000 academic year to staff and students of Cambridge Institute for Medical Research (CIMR), University of Cambridge and the Medical Research Council Laboratory of Molecular Biology, Cambridge (MRC-LMB).<br />
<br />
{| class="wikitable" <br />
|-<br />
! colspan="3" | <b>Lecture Topics</b><br />
|-<br />
| colspan="3" | <br /><b>Basic concepts and practical aspects</b><br />
|-<br />
| [http://www.phaser.cimr.cam.ac.uk/Course/Overview/Overview.html Overview of X-ray crystallography]<br />
| Randy Read<br />
| 9 November 1999<br />
|-<br />
| [https://www.phaser.cimr.cam.ac.uk/Course/Crystals/intro.html Crystallisation: theory and practice]<br />
| Airlie McCoy<br />
| 16 November 1999<br />
|-<br />
| [https://www.phaser.cimr.cam.ac.uk/Course/Basic_diffraction/Diffraction.html Basic diffraction theory: waves, interference, reciprocal space]<br />
| Randy Read<br />
| 23 November 1999<br />
|-<br />
| [https://www.phaser.cimr.cam.ac.uk/Course/Basic_collection/Datacol.html X-ray data collection: indexing, strategy, processing]<br />
| Andrew Leslie<br />
| 30 November 1999<br />
|-<br />
| [https://www.phaser.cimr.cam.ac.uk/Course/Basic_phasing/Phasing.html The phase problem: introduction to phasing methods]<br />
| Randy Read<br />
| 7 December 1999<br />
|-<br />
| [https://www.phaser.cimr.cam.ac.uk/Course/Basic_refinement/Refinement.html Introduction to fitting, refinement and validation]<br />
| Randy Read<br />
| 14 December 1999<br />
|-<br />
| colspan="3" | <br /><b>Advanced topics</b><br />
|-<br />
| [https://www.phaser.cimr.cam.ac.uk/Course/Adv_diff1/Diffraction.html Advanced diffraction: waves, interference and complex numbers]<br />
| Randy Read<br />
| 18 January 2000<br />
|-<br />
| [https://www.phaser.cimr.cam.ac.uk/Course/Adv_diff2/Diffraction2.html Advanced diffraction:atoms, crystals and reciprocal space]<br />
| Randy Read<br />
| 25 January 2000<br />
|-<br />
| X-ray sources: from generators to synchrotrons<br />
| Gwyndaf Evans<br />
| 8 February 2000<br />
|-<br />
| Data collection, processing, complications<br />
| Andrew Leslie<br />
| 15 February 2000<br />
|-<br />
| [https://www.phaser.cimr.cam.ac.uk/Course/Fourier/Fourier.html Fourier transforms: structure factors, phases and electron density]<br />
| Randy Read<br />
| 22 February 2000<br />
|-]<br />
| [https://www.phaser.cimr.cam.ac.uk/Course/Convolution/convolution.html The convolution theorem and its applications]<br />
| Randy Read<br />
| 29 February 2000 <br />
|-<br />
| Symmetry in real and reciprocal space<br />
| Anne Bloomer<br />
| 7 March 2000<br />
|-<br />
| The Patterson function and its implications<br />
| Phil Evans<br />
| 28 March 2000<br />
|-<br />
| [https://www.phaser.cimr.cam.ac.uk/Course/Statistics/statistics.html Structure factor statistics: Wilson statistics, SIGMAA...]<br />
| Randy Read<br />
| 4 April 2000<br />
|-<br />
| [https://www.phaser.cimr.cam.ac.uk/Course/Likelihood/likelihood.html Maximum likelihood: theory, and application to structure refinement]<br />
| Randy Read<br />
| 11 April 2000<br />
|-<br />
| [https://www.phaser.cimr.cam.ac.uk/Course/MolRep/molrep.html Molecular replacement]<br />
| Randy Read<br />
| 18 April 2000<br />
|-<br />
| Isomorphous replacement<br />
| Randy Read<br />
| 25 April 2000<br />
|-<br />
| [https://www.phaser.cimr.cam.ac.uk/Course/Adv_phasing/Expphasing.html Experimental phasing by maximum likelihood]<br />
| Randy Read<br />
| not presented <br />
|-<br />
| Anomalous scattering and MAD<br />
| Gwyndaf Evans<br />
| 2 May 2000<br />
|-<br />
| [https://www.phaser.cimr.cam.ac.uk/Course/DenMod/index.htm Density modification: theory and practice]<br />
| Randy Read<br />
| 9 May 2000<br />
|-<br />
| [https://www.phaser.cimr.cam.ac.uk/Course/Fitting/fittingtalk.html Fitting, refinement and validation]<br />
| Phil Evans<br />
| 16 May 2000<br />
|-<br />
| Analysing protein structures<br />
| Arthur Lesk<br />
| 23 May 2000<br />
|}</div>
WikiSysop