Course

The Macromolecular Crystallography course was presented in the 1999-2000 academic year to staff and students of CIMR, University of Cambridge and the MRC-LMB.

Lecture Topics
Basic concepts and practical aspects
Overview of X-ray crystallography	Randy Read	9 November
Crystallisation: theory and practice	Airlie McCoy	16 November
[https://www.phaser.cimr.cam.ac.uk/Course/Basic_diffraction/Diffraction.html Basic diffraction theory: waves, interference, reciprocal space	Randy Read	23 November
X-ray data collection: indexing, strategy, processing	Andrew Leslie	30 November
The phase problem: introduction to phasing methods	Randy Read	7 December
[https://www.phaser.cimr.cam.ac.uk/Course/Basic_phasing/Phasing.html Introduction to fitting, refinement and validation	Randy Read	14 December
Advanced topics
Advanced diffraction: waves, interference and complex numbers	Randy Read	18 January
Advanced diffraction:atoms, crystals and reciprocal space	Randy Read	25 January
X-ray sources: from generators to synchrotrons	Gwyndaf Evans	8 February
Data collection, processing, complications	Andrew Leslie	15 February
Fourier transforms: structure factors, phases and electron density	Randy Read	22 February
The convolution theorem and its applications	Randy Read	29 February
Symmetry in real and reciprocal space	Anne Bloomer	7 March
The Patterson function and its implications	Phil Evans	28 March
Structure factor statistics: Wilson statistics, SIGMAA...	Randy Read	4 April
Maximum likelihood: theory, and application to structure refinement	Randy Read	11 April
Molecular replacement	Randy Read	18 April
Isomorphous replacement	Randy Read	25 April
Experimental phasing by maximum likelihood	Randy Read	not presented
Anomalous scattering and MAD	Gwyndaf Evans	2 May
Density modification: theory and practice	Randy Read	9 May
Fitting, refinement and validation	Phil Evans	16 May
Analysing protein structures	Arthur Lesk	23 May