Course

The Macromolecular Crystallography course was presented in the 1999-2000 academic year to staff and students of Cambridge Institute for Medical Research (CIMR), University of Cambridge and the Medical Research Council Laboratory of Molecular Biology, Cambridge (MRC-LMB).

Lecture Topics
Basic concepts and practical aspects
Overview of X-ray crystallography	Randy Read	9 November 1999
Crystallisation: theory and practice	Airlie McCoy	16 November 1999
Basic diffraction theory: waves, interference, reciprocal space	Randy Read	23 November 1999
X-ray data collection: indexing, strategy, processing	Andrew Leslie	30 November 1999
The phase problem: introduction to phasing methods	Randy Read	7 December 1999
Introduction to fitting, refinement and validation	Randy Read	14 December 1999
Advanced topics
Advanced diffraction: waves, interference and complex numbers	Randy Read	18 January 2000
Advanced diffraction:atoms, crystals and reciprocal space	Randy Read	25 January 2000
X-ray sources: from generators to synchrotrons	Gwyndaf Evans	8 February 2000
Data collection, processing, complications	Andrew Leslie	15 February 2000
Fourier transforms: structure factors, phases and electron density	Randy Read	22 February 2000
The convolution theorem and its applications	Randy Read	29 February 2000
Symmetry in real and reciprocal space	Anne Bloomer	7 March 2000
The Patterson function and its implications	Phil Evans	28 March 2000
Structure factor statistics: Wilson statistics, SIGMAA...	Randy Read	4 April 2000
Maximum likelihood: theory, and application to structure refinement	Randy Read	11 April 2000
Molecular replacement	Randy Read	18 April 2000
Isomorphous replacement	Randy Read	25 April 2000
Experimental phasing by maximum likelihood	Randy Read	not presented
Anomalous scattering and MAD	Gwyndaf Evans	2 May 2000
Density modification: theory and practice	Randy Read	9 May 2000
Fitting, refinement and validation	Phil Evans	16 May 2000
Analysing protein structures	Arthur Lesk	23 May 2000